1-[4-(2-chlorophenoxy)butyl]imidazole

Description

1-[4-(2-chlorophenoxy)butyl]imidazole, also known as **butaconazole**, is a synthetic antifungal agent belonging to the imidazole class. It has a wide range of applications in research, including:

**1. Antifungal Activity:**

* Butaconazole exhibits **potent antifungal activity** against a broad spectrum of fungal pathogens, including dermatophytes, yeasts, and molds.
* It acts by **inhibiting the synthesis of ergosterol**, a key component of fungal cell membranes. This disruption leads to cell membrane dysfunction and ultimately, fungal cell death.

**2. Research on Fungal Pathogenesis:**

* As a potent antifungal agent, butaconazole is used in **research studies investigating the mechanisms of fungal pathogenesis.**
* It helps researchers understand how fungal cells grow, proliferate, and cause infections.
* Butaconazole is also used to develop **new antifungal drugs with improved efficacy and safety profiles.**

**3. Model System for Studying Drug Resistance:**

* Butaconazole is used as a **model compound to study the development of drug resistance in fungi**.
* Understanding how fungi develop resistance to butaconazole can help researchers develop strategies to overcome these challenges and maintain the effectiveness of antifungal therapies.

**4. Agricultural Research:**

* Butaconazole is also used in **agricultural research to control fungal diseases in crops**.
* It helps protect crops from fungal pathogens, improving crop yields and reducing economic losses.

**5. Veterinary Research:**

* Butaconazole is used in **veterinary research to treat fungal infections in animals**.
* It helps veterinarians control fungal infections in pets and livestock, improving animal health and welfare.

**Overall, 1-[4-(2-chlorophenoxy)butyl]imidazole (butaconazole) is a versatile antifungal agent that plays a crucial role in research, aiding in understanding fungal pathogenesis, developing new antifungal drugs, and improving the control of fungal infections in various settings.**

1-[4-(2-chlorophenoxy)butyl]imidazole : An aromatic ether that is 2-chlorophenol in which the phenolic hydrogen has been substituted by a 4-(1H-imidazol-1-yl)butyl group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]